First evidence of TRPV 5 and TRPV 6 channels in human parathyroid glands: possible involvement in neoplastic transformation

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First evidence of TRPV5 and TRPV6 channels in human parathyroid glands: possible involvement in neoplastic transformation

The parathyroid glands play an overall regulatory role in the systemic calcium (Ca(2+)) homeostasis. The purpose of the present study was to demonstrate the presence of the Ca(2+) channels transient receptor potential vanilloid (TRPV) 5 and TRPV6 in human parathyroid glands. Semi-quantitative and quantitative PCR was carried out to evaluate the presence of TRPV5 and TRPV6 mRNAs in sporadic para...

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The past year has seen a doubling in the number of heat-sensitive ion channels to six, and four of these channels are from the TRPV family. These channels characteristically have Q(10) values of >10 above the thermal threshold, very different from the Q(10) values of 1.5-2.0 seen in most ion channels. Cells expressing TRPV1 show similar temperature sensitivity to small capsaicin-sensitive nocic...

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Hot flash: TRPV channels in the brain.

TRPV1 (transient receptor potential, vanilloid) channels belong to a family of ligand-gated ion channels gated not only by the binding of certain lipophilic molecules but also by extracellular protons and physical stimuli such as heat or osmotic pressure changes. These nonselective cation channels are permeable to Na(+) and K(+) and are also very Ca(2+) permeable; in fact, TRPV1 is as Ca(2+) pe...

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A molecular determinant of phosphoinositide affinity in mammalian TRPV channels

Phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] is an important cofactor for ion channels. Affinity for this lipid is a major determinant of channel inhibition by depletion of PI(4,5)P2 upon phospholipase C (PLC) activation. Little is known about what determines PI(4,5)P2 affinity in mammalian ion channels. Here we report that two members of the Transient Receptor Potential Vanilloid (TRPV) i...

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Activation of a Presynaptic TRPV-Like Receptor

30 Recent studies have found that some forms of endocannabinoid-dependent synaptic 31 plasticity in the hippocampus are mediated through activation of transient potential receptor 32 vanilloid (TRPV) receptors instead of cannabinoid receptors CB1 or CB2. The potential role for 33 synaptic localization of TRPV receptors during endocannabinoid modulation of nociceptive 34 synapses was examined in...

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ژورنال

عنوان ژورنال: Journal of Cellular and Molecular Medicine

سال: 2014

ISSN: 1582-1838,1582-4934

DOI: 10.1111/jcmm.12372